Early dialysis may not improve kidney failure outcomes
by Nancy Walsh
Planned early initiation of dialysis in patients with chronic kidney disease did not improve survival or other clinical outcomes, a multicenter randomized trial conducted in Australia and New Zealand found.
The hazard ratio for death among patients who had an early start of dialysis, when the estimated glomerular filtration rate (GFR) was 10 to 14 mL/min, was 1.04 (95% CI 0.83 to 1.30, P=0.75), according to Bruce A. Cooper, MBBS, PhD, of Sydney (Australia) Medical School, and colleagues.
This was in comparison with patients who had a later start, when the estimated GFR was 5 to 7 mL/min, the investigators reported at the European Renal Association-European Dialysis and Transplant Association Congress in Munich. The findings were concurrently published online by the New England Journal of Medicine.
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